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Development and optimization of a gas chromatography/mass spectrometry method for the analysis of thermochemolytic degradation products of phthiocerol dimycocerosate waxes found in Mycobacterium tuberculosis

Identifieur interne : 000702 ( Main/Exploration ); précédent : 000701; suivant : 000703

Development and optimization of a gas chromatography/mass spectrometry method for the analysis of thermochemolytic degradation products of phthiocerol dimycocerosate waxes found in Mycobacterium tuberculosis

Auteurs : Simona C. Nicoara [Royaume-Uni, Roumanie] ; David E. Minnikin [Royaume-Uni] ; Oona C. Y. Lee [Royaume-Uni] ; Denise M. O'Sullivan [Royaume-Uni] ; Ruth Mcnerney [Royaume-Uni] ; Collin T. Pillinger [Royaume-Uni] ; Ian P. Wright [Royaume-Uni] ; Geraint H. Morgan [Royaume-Uni]

Source :

Rapid Communications in Mass Spectrometry [ 0951-4198 ] ; 2013-11-15.

RBID : ISTEX:C3EA819BE3BBCE8FFBD546FE8CC45A7799A786FC

Abstract

The phthiocerol dimycocerosates (PDIMs) are certain stable and hydrophobic waxes found in the cell membrane of Mycobacterium tuberculosis, bacteria that cause an infectious disease of growing concern worldwide. Previous studies report the analysis of derivatives of the hydrolysed PDIMs from biological samples, following complex extraction and offline derivatization of PDIMs biomarkers, prior to their analysis by gas chromatography/mass spectrometry (GC/MS).

Url:

https://api.istex.fr/document/C3EA819BE3BBCE8FFBD546FE8CC45A7799A786FC/fulltext/pdf

DOI: 10.1002/rcm.6694

Affiliations:

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Le document en format XML

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<front><div type="abstract">The phthiocerol dimycocerosates (PDIMs) are certain stable and hydrophobic waxes found in the cell membrane of Mycobacterium tuberculosis, bacteria that cause an infectious disease of growing concern worldwide. Previous studies report the analysis of derivatives of the hydrolysed PDIMs from biological samples, following complex extraction and offline derivatization of PDIMs biomarkers, prior to their analysis by gas chromatography/mass spectrometry (GC/MS).</div>
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Development and optimization of a gas chromatography/mass spectrometry method for the analysis of thermochemolytic degradation products of phthiocerol dimycocerosate waxes found in Mycobacterium tuberculosis

Development and optimization of a gas chromatography/mass spectrometry method for the analysis of thermochemolytic degradation products of phthiocerol dimycocerosate waxes found in Mycobacterium tuberculosis

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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